Til forskere
English page for scientists:
Publications, Data availability and Collaborations
About
BIOSKIN
Dansk
I mange år har det været en udfordring for forskere at forstå, hvorfor hudsygdomme som psoriasis og eksem påvirker nogle mennesker mere end andre, hvorfor nogle patienter udvikler følgesygdomme, og hvorfor visse patienter ikke reagerer på behandling. BIOSKIN- forskningsprogrammet, herunder en biobank, arbejder på at ændre dette ved at kaste lys over, hvordan hudsygdomme udvikler sig hos patienter over tid.
Målet er at indsamle kliniske data samt hud- og blodprøver fra 3.000 patienter for at opnå ny indsigt i nogle af de mest almindelige hudsygdomme som psoriasis og eksem. Patienterne vil blive fulgt nøje over en periode på minimum fem år. Biobanken er den første af sin art og har til formål at gøre ny viden tilgængelig for forskere globalt til gavn for patienter med hudsygdomme. Biobanken vil i høj grad fremskynde processen med at omsætte nye ideer til konkrete resultater.
Kernen i forskningsprogrammet er det tætte samarbejde mellem kliniske og basale forskere på tværs af hospital og universitet. Gennem dette tværfaglige samarbejde og den tætte kontakt til patienter via patientorganisationer sikres at patienternes behov sættes i fokus. Programmet giver en enestående mulighed for at indsamle data samt hud- og blodprøver fra de samme patienter over flere år. Dette åbner nye videnskabelige perspektiver, som i sidste ende kan føre til mere effektive behandlinger.
English
For many years, researchers have had difficulties decoding why skin diseases such as psoriasis and eczema affect some people more than others, why some patients develop comorbidities and why some patients do not respond to treatment. The BIOSKIN research program – including a biobank – is about to change that by elucidating how skin diseases develop in patients over time.
The goal is to collect clinical data and skin and blood samples from 3,000 patients to gain new insights about some of the most common skin diseases such as psoriasis and eczema. Patients will be followed closely over a period of minimum five years.
The biobank is the first of its kind and aims to make new knowledge available to the research community across the world for the benefit of patients with skin diseases. The biobank will significantly affect how fast we are able to turn novel ideas into tangible results.
Close collaboration between clinical and basic researchers across hospital and university is at the core of the research program. Along with close contact to patients through patient organizations, this interdisciplinary collaboration will ensure significant impact for patients.
The program provides a unique opportunity to collect data and skin and blood samples from the same patients over the course of several years, creating new possibilities in science, which can ultimately lead to more effective treatments.
Latest
Publications
BIOSKIN: A Protocol for the Copenhagen Translational Skin Immunology Biobank and Research Programme
Marianne Bengtson Løvendorf, Jeanne Duus Johansen, Lone Skov, BMJ Open, 2024 Feb 24;14(2):e077207, PMID: 38401898
Abstract (https://bmjopen.bmj.com/content/14/2/e077207)
Stratum Corneum Lipids in Non-Lesional Atopic and Healthy Skin following Moisturizer Application: A Randomized Clinical Experiment
Malin Glindvad Ahlström, Rie Dybboe Bjerre, Magnus Glindvad Ahlström, Lone Skov, Jeanne Duus Johansen, Life, 2024;14(3):345.
Abstract (https://pmc.ncbi.nlm.nih.gov/articles/PMC10971083/)
Mapping the Periostin Splice Isoforms in Atopic Dermatitis and an in vitro Asthma Model. A Multi-Platform Analysis Using mass spectrometry and RT-qPCR
Christian E. Rusbjerg-Weberskov; Anne Kruse Hollensen; Christian Kroun Damgaard; Marianne Bengtson Løvendorf; Lone Skov; Jan J. Enghild; Nadia Sukusu Nielsen, Biochim Biophys Acta Proteins Proteom, 2024 Sep 1;1872(5):141031.
Abstract (https://pubmed.ncbi.nlm.nih.gov/38977230/)
Assessment of metabolic dysfunction-associated steatotic liver disease in patients with hidradenitis suppurativa: A cross-sectional study
N Omari, S Simonsen, L L Gluud, H M Martin, M B Trelle, G B Jemec, L Skov, C Näslund-Koch, J Eur Acad Dermatol Venereol, 2024 May 19. doi: 10.1111/jdv.20110.
Abstract (https://pubmed.ncbi.nlm.nih.gov/38764439/)
Atopic dermatitis and hand eczema in Danish adults: A nationwide population-based study
Anna Schultz Vinge, Lone Skov, Jeanne Duus Johansen, Anna Sophie Quaade, Contact Dermatitis, 2024 Sep 12., doi: 10.1111/cod.14691.
Abstract (https://pubmed.ncbi.nlm.nih.gov/39264018/)
The global epidemiology of vitiligo: A systematic review and meta‐analysis of the incidence and prevalence
Morten Bahrt Haulrig, Rownaq Al‐Sofi, Subisan Baskaran, Mie Siewertsen Bergmann, Marianne Bengtson Løvendorf, Beatrice Dyring‐Andersen, Lone Skov, Nikolai Loft, JEADV, Clin Pract, 2024, 1-10, doi: 10.1002/jvc2.526
Abstract (https://onlinelibrary.wiley.com/doi/full/10.1002/jvc2.526)
Sex Differences in Dermatology Life Quality Index (DLQI) among Patients with Psoriasis
Mikkel Bak Jensen, Nikolai Loft, Claus Zacheriae, Lone Skov, Acta Derm Venereol, 2024 Dec 5:104:adv42441. doi: 10.2340/actadv.v104.42441.
Abstract (https://pubmed.ncbi.nlm.nih.gov/39636070/)
Biomarkers of Extracellular Matrix Fragments in Patients with Psoriasis
Mila Broby Johansen, Signe Holm Nielsen,Helena Port,Tanja Todberg, Marianne Bengtson Løvendorf, Lone Skov, Int. J. Mol. Sci. 2025, 26(1), 261; https://doi.org/10.3390/ijms26010261
Abstract (https://www.mdpi.com/1422-0067/26/1/261)
Multiple Biologics Treatment Failures in Patients with Psoriasis: A Case Series of 4 Patients
Mikkel Bak Jensen, Nikolai Loft, Claus Zachariae, Lone Skov, Acta Derm Venereol. 2025 Mar 9:105:adv42987. doi: 10.2340/actadv.v105.42987.
Abstract (https://pmc.ncbi.nlm.nih.gov/articles/PMC11904832/)
Latest data
Data availability
Clinical data obtained in BIOSKIN are recorded and managed using a Research Electronic Data Capture tool (REDCap) hosted at the Capital Region of Denmark (Region H) which ensures uniform and high-quality data collection following the FAIR principles (Findable, Accessible, Interoperable and Reusable). Genetic information will be stored at the National Genome Centre according to §223a of the Danish Health Act, BEK no. 360 of 4 April 2019.
Researchers can request access to the data collected in this project. Access will be granted in compliance with legal and ethical guidelines to ensure the privacy and confidentiality of all patient information. This data-sharing approach aims to foster collaboration and advance scientific knowledge while adhering to strict data protection standards.
Valued
Collaborations
Collaborations are at the heart of our research efforts, and we are fortunate to have valuable national and international partnerships.
Our academic collaborators bring diverse expertise, enriching the scientific foundations of our work. In addition, our partnerships with patient organizations and patient panels are crucial in ensuring that our research remains patient-centered and directly aligned with the needs of those affected by skin diseases. These collaborations are key to bridging clinical and basic research, fostering a strong translational research effort that ensures scientific discoveries are effectively translated into practical applications for patient care. This collaborative approach strengthens the impact of our work, allowing us to tackle complex challenges, share knowledge, and ultimately improve outcomes for patients.
We are open to new collaborations and actively seek to expand our network of partners to further enhance the scope and reach of our research. If you are interested in collaborating with us, please feel free to contact us.